MULTIPLE VIRTUAL SCREENING APPROACHES FOR FINDING NEW HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: STRUCTURE-BASED SCREENS AND MOLECULAR DYNAMICS FOR THE PURSUE OF NEW POLY PHARMACOLOGICAL INHIBITORS

Multiple virtual screening approaches for finding new Hepatitis c virus RNA-dependent RNA polymerase inhibitors: Structure-based screens and molecular dynamics for the pursue of new poly pharmacological inhibitors

Abstract The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites.This work presents a workflow for virtual screening and its application to Drug Chillum Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleoside binding sites.Potential polyp

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MULTISPECTRAL AERIAL IMAGES TO SUPPORT BIOTOPE INFORMATION SYSTEMS FOR MIDGE INFESTATION AND BARK BEETLE MONITORING

Monitoring environmental phenomena with assistance of remotely captured data is increasingly important in environmental studies.The observation of midge infestation or bark beetles can be considered a non-direct approach to their environments or in some cases to their impact on the ecosystem.Multispectral or hyper spectral data captured by aircraft

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HIV Testing and HIV Positivity Among People Who Inject Drugs (PWIDs) With and Without History of High-Risk Behaviors: Findings From a Respondent-Driven Sampling (RDS) Survey in Southern Thailand

People who inject drugs (PWIDs) may engage in other behaviors with high Table Cloth risk of HIV transmission to various extents.However, data are scarce regarding differences in HIV testing and HIV positivity among PWIDs with and without high-risk behaviors.Such data can help inform stakeholders with regard to program prioritization.The objective o

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