MULTIPLE VIRTUAL SCREENING APPROACHES FOR FINDING NEW HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE INHIBITORS: STRUCTURE-BASED SCREENS AND MOLECULAR DYNAMICS FOR THE PURSUE OF NEW POLY PHARMACOLOGICAL INHIBITORS

Abstract The RNA polymerase NS5B of Hepatitis C virus (HCV) is a well-characterised drug target with an active site and four allosteric binding sites.This work presents a workflow for virtual screening and its application to Drug Chillum Bank screening targeting the Hepatitis C Virus (HCV) RNA polymerase non-nucleoside binding sites.Potential polyp

A view continues to gain momentum that regards investigation of the cognition of great apes in captive settings as affording us a model for human cognitive evolution.Researchers from disciplines such as comparative psychology, anthropology, and even archaeology, seem eager to put their theories to the test by using great apes as their chosen experi

Monitoring environmental phenomena with assistance of remotely captured data is increasingly important in environmental studies.The observation of midge infestation or bark beetles can be considered a non-direct approach to their environments or in some cases to their impact on the ecosystem.Multispectral or hyper spectral data captured by aircraft

People who inject drugs (PWIDs) may engage in other behaviors with high Table Cloth risk of HIV transmission to various extents.However, data are scarce regarding differences in HIV testing and HIV positivity among PWIDs with and without high-risk behaviors.Such data can help inform stakeholders with regard to program prioritization.The objective o